Method of preparing benzothiazepine derivatives

ABSTRACT

A benzothiazepine derivative of the formula:   &lt;IMAGE&gt; (I)  wherein R is hydrogen or acetyl, is prepared by condensing a compound of the formula:   &lt;IMAGE&gt; (II)  wherein R is the same as defined above, with 2-(diamethylamino)ethyl halide (i) in the presence of potassium hydroxide in acetone; or (ii) in the presence of potassium carbonate in acetone, lower alkyl acetate, a mixture of acetone and water or a mixture of lower alkyl acetate and water.



